The interactions between sound waves and living tissue were first observed and reported in the early 20th Century [1, 2]. Since then ultrasound-based therapies have been used to treat a very wide range of medical disorders . Ultrasound stimulation accelerates the bone fracture repair process [4, 5]. Therapeutic ultrasound is also commonly employed to manage soft tissue lesions . The ability of ultrasound to focus through the skull noninvasively has lately made it an attractive technique for neuromodulation to treat neurological disorders . More recently, ultrasound has also been shown to remove amyloid plaque and restore memory in an Alzheimer’s disease mouse model . In addition to the beneficial therapeutic benefits of high intensity sound irradiation , sound may lead to harmful effects on health. The evaluation of the risks of routine prenatal ultrasound imaging on a fetus during pregnancy has not considered the possible effect on intercellular signaling identified here . It is also known that exposure to traffic noise in addition to that of air pollution leads to an increase in risk of cardio-vascular diseases [11, 12]. The mechanisms driving the effect of noise exposure on the function of the cardio-vascular system are essentially unknown. Finally, vibro-acoustic disease (VAD) is a pathology that develops in individuals excessively exposed to low frequency sound . VAD is associated with the abnormal growth of extra-cellular matrices (collagen and elastin), in the absence of an inflammatory process seen in blood vessels, cardiac structures, trachea, lung, and kidney. VAD appears to be a mechano-transduction disease resulting from impairment of mechanically mediated signaling in exposed tissues . The effects of the physical parameters of the sound on signaling, such as frequency or intensity (amplitude), are essentially unknown. The paradigm-changing scientific foundations laid by NewFoS will maximize the positive impacts of sound waves and phonons on society through breakthroughs such as: (1) improved public health by mitigating the effects of noise in urban and industrial environments; (2) enriched individual health from revolutionary sound-based precision diagnostic and therapeutic technologies
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