NewFoS will also drive innovation through its seed research program for possibility-driven research. Our aim is to invest in promising new TA research directions, where seed-level support sprouts new ideas in underexplored TA application areas and ultimately defines new problem-driven research projects. We will explore opportunities in biomedical engineering and medical sciences to create possibilities for better diagnostics, precision and safer drug delivery, and the therapeutic effects of sound. The seed program will be a mechanism to dynamically evolve the NewFoS research portfolio for maximal societal impacts.
2023-2024 Possibility-driven project leads: M. Kim (UA) and Ding (UCB).
Prolonged exposure to noise is a major environment-related cause of ill health, including cardiovascular diseases. Exposure to sound has also therapeutic virtues. The therapeutic and ill-health effects of sound on biological processes are essentially unknown or speculative. This seed project will investigate the effect of sound irradiation on intercellular Ca2+ signals in tissues composed of endothelial cells with an emphasis on time reversal and parity symmetry breaking. Ca2+ is a universal messenger and mediates dynamics in cell functions. NewFoS research tasks and products: We will identify and experimentally study the phenomena of nonconventional topology and nonreciprocity of propagation for gap-junctions-based intercellular signaling induced by acoustic irradiation.
